Available on line in the Bibliographic Review section the new paper “Immunotherapy and malignant pleural mesothelioma”.
Malignant Pleural Mesothelioma is considered an “inflammatory” tumor because it is often characterized by a prominent infiltration of lymphocytes, macrophages and T-cells. The continuous, chronic inflammation of the mesothelial cells helps transform these healthy cells into cancer cells. Similarly, the escape mechanisms from the immune system allow the tumor to evade the immune response from the host.
A new frontier in medical research involves the study of immune mechanisms that allow the tumor to grow by evading our body’s controls. The purpose of this revision of the scientific literature is to provide an overview of the research being conducted to identify suitable targets for an effective immunotherapy for MPM.